Synergistic effect of PLLA and PN (Polynucleotide) for collagenesis and tissue regeneration
PLLA uniform structure of spherical microparticles improves the safety and efficacy in volume restoration. Anti-inflammatory property of PN controls the foreign body reaction and promotes cell proliferation. Fundamental improvements from physical restoration to collagen production and tissue regeneration.
PLLA microparticle structure
The uniform size (30-50µm) and structure of PLLA particles from the emulsification technique prevent nodule formation or injection needle/cannula clogging (27–32G). The smooth microsphere surface without microholes allows quick dilution and even distribution of the particles in the emulsion state.
PN synergistic effect
The physical restoration of PLLA particles under skin accompanies a foreign body reaction involving initial inflammatory responses. The included PN inhibits the inflammatory cytokine initially and promotes cell proliferation by activating essential growth factors. The mechanism contributes for collagenesis and angiogenesis effects eventually leading to the tissue regeneration. Not only with the physical stimulation of fibroblast (mechanotransduction), but the restoration property of PN shows the ideal synergistic effect simultaneously.
After Injection
Physical Support
Under the skin, Etrebelle PN physically supports the injected area with its material properties, while non-cross-linked HA distributes the PLA particles internally. PN particles inhibit inflammatory responses from the foreign body reaction.
After 1 Month
Restoration
With the natural degradation of HA material, PLA particles evenly take position, resulting in the initial volumizing effects. PN particles initiate the activation of essential growth factors and stimulate fibroblasts.
After 6 Months
Maintenance
PLA particles have now fully integrated with the skin tissue structure, inducing a collagenesis effect. PN particles contribute to cell proliferation through the secretion of growth factors.
After 24 Months
Elimination
The PLA particles and naturally induced collagen are now indistinguishable. The promoted collagenesis effect and fibroblast stimulation enrich both extracellular components and the skin tissue environment.
Skin elasticity improvement, Fine wrinkle removal
Contouring facial line
Etrebelle PN
(PLA: 150mg + PN 35mg + HA: 15mg)
PLA particle: 30-50μm
PN Particle : 1,000 kDa
HA particle: 1,400kDa
Mixture: Sterile distilled water 6cc + Lidocaine 1cc
(dilution time: over 30min)
Cannula size: 27-32G
