Collaju – Atelocollagen Injectable

Collaju logo

A New Era of Collagen — Atelocollagen

More than simply replenishing collagen lost due to aging and environmental stress, Atelocollagen provides immediate volumizing support while helping reinforce the skin’s structural foundation for a firmer, fuller, and healthier-looking appearance.

Collaju atelocollagen pre-filled syringe

Premium Atelocollagen

Natural yet powerful raw material, Atelocollagen, meets CE and ISO 13485 standards.

Pure 99.0% Collagen

Formulated with 99% Collagen for versatile use, delivering a skin-boosting and volumizing effect.

Safe Injection

Immunogenicity minimized through enzymatic refinement and advanced multi-filtration.

Excellent Biocompatibility

Human-like collagen, purified in a non-crosslinked state, enriches the skin’s ECM environment. Utilized via low-heat aseptic salt precipitation technique (Patent No. 10-1105603).

#High Tensile Strength
#ECM Structure Role
#Cell Proliferation Support
#Minimize Inflammatory Reaction
#Flexibility
#Gene Transfer Role

NOT ONLY

Volumizing filler

NOT A TYPICAL

Particulate biostimulator

DIRECT Injectable

ECM protein

The material (Collaju) has experienced consistent growth since receiving approval from KFDA in 2015.

Starting with the first registration at Uijeongbu St. Mary’s Hospital in 2016, it has been adopted by domestic university hospitals such as Seoul St. Mary’s Hospital, Seoul National University Hospital, Seoul National University Bundang Hospital, Seoul Asan Medical Center, and Samsung Seoul Medical Center, and as of the end of 2023, it’s registered in approximately 67 university hospitals in Korea.

Samsung Medical Center logoSeoul St. Mary's Hospital, The Catholic University of Korea logoAsan Medical Center logoSeoul National University Hospital (SNUH) logo

Atelocollagen (Type I)

Type I atelocollagen is treated with pepsin to remove telopeptides, reducing immunogenicity while preserving collagen’s structure and function.

Collagen Structure

BCollagen is made of two α1 chains and one α2 chain, with telopeptides at both ends, which increase immunogenicity.

Collagen Types

Of the 28 known types, Type I is the most abundant. It weighs ~300 kDa and has three polypeptide chains.

Consistent Collagen Fiber Structure for Stability

Electron microscope images comparing collagen fiber structure: Collaju shows thick, aligned fiber bundles versus disordered fibers in Product A and Product B
Light microscope and stained images comparing collagen fibers: Collaju forms dense, consistent fiber networks versus Product A and Product B

High temperature precipitation

Diagram: high-temperature precipitation denatures atelocollagen into gelatin, producing thin collagen fibers with high antigenicity

Collaju low temperature precipitation

Diagram: Collaju's low-temperature aseptic salt precipitation keeps atelocollagen intact, forming thick collagen fibers with low antigenicity and low inflammation potential

The thick, structured Atelocollagen matrix provides strong support for the skin while replenishing collagen lost over time. It helps restore a healthy skin environment, reinforcing skin structure and bringing it back to a healthier condition with a natural-looking effect.